This is a broad clinical and histologic category of diseases. The major mucinoses are listed below. Mucin is a common secondary finding in many disorders of the skin, both benign and malignant. Lupus erythematosus, for example, classically has abundant dermal mucin. The following list showcases some of the primary mucinosis.
Reticular erythematous mucinosis
Acral persistent papular mucinosis
Digital mucous cyst
Cutaneous mucinosis of infancy
Alopecia mucinosa (Follicular mucinosis)
Jessner's lymphocytic infiltrate
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CLINICAL VARIANTS CHARACTERIZATION SELF-HEALING JUVENILE CUTANEOUS MUCINOSIS
- J Am Acad Dermatol. 2006 Dec;55(6):1036-43. Abstract quote
BACKGROUND: Self-healing juvenile cutaneous mucinosis is a rare disease affecting young people characterized by transient cutaneous lesions and sometimes mild inflammatory symptoms. The deep dermal and subcutaneous features of this disorder have not yet been well described.
OBJECTIVE: The purpose of our study was to present 3 cases of self-healing juvenile cutaneous mucinosis in which the histopathologic features caused diagnostic confusion between this disorder and proliferative fasciitis.
METHODS: The study includes clinical and histologic findings of 3 patients, complemented by a literature review. RESULTS: The histologic descriptions of nodular lesions in self-healing juvenile cutaneous mucinosis reveal features of proliferative fasciitis, including a myxoid stroma and gangliocyte-like giant cells.
LIMITATIONS: Self-healing juvenile cutaneous mucinosis is a rare condition and has not been frequently reported in medical literature. Our findings are based on the pathologic features of 3 patients.
CONCLUSIONS: Our findings further elucidate the histologic features of self-healing juvenile cutaneous mucinosis and expand the differential diagnosis for entities in which gangliocyte-like giant cells are noted.
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Sternberg S. Diagnostic Surgical Pathology. Fourth Edition. Lipincott Williams and Wilkins 2004.
Robbins Pathologic Basis of Disease. Seventh Edition. WB Saunders 2005.
DeMay RM. The Art and Science of Cytopathology. Volume 1 and 2. ASCP Press. 1996.
Weedon D. Weedon's Skin Pathology Second Edition. Churchill Livingstone. 2002
Fitzpatrick's Dermatology in General Medicine. 6th Edition. McGraw-Hill. 2003.
Weiss SW and Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. Fourth Edition. Mosby 2001.
Alcian blue-Common stain used at pH 2.5 to demonstrate mucin.
Colloidal iron-Common stain used to demonstrate mucin.
Glycosaminoglycans-Acid mucopolysaccharides present in the dermis. Produced by fibroblasts and bind minerals and water.
Hyaluronic acid -One type of glycosaminoglycan, unattached to proteins.
Proteoglycans-Glycosaminoglycans attached to proteins.
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Last Updated December 7, 2006
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