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Hypothyroidism causes several skin changes. This is one of the most common occurring as a slight thickening of the skin aorund the eyes, nose, cheeks, and distal extremities. Rarely, palmoplantar keratoderma may be present.

Biopsy of the skin reveals a subtle increase of mucin within the dermis, usually around hair follicles and the blood vessels. There is no increase in fibroblasts.

J Cutan Pathol 1985;12:334.
Henry JB. Clinical Diagnosis and Management by Laboratory Methods. Twentieth Edition. WB Saunders. 2001.
Rosai J. Ackerman's Surgical Pathology. Eight Edition. Mosby 1996.
Sternberg S. Diagnostic Surgical Pathology. Third Edition. Lipincott Williams and Wilkins 1999.
Weedon D. Weedon's Skin Pathology. Churchill Livingstone. 1997.
Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.
Robbins Pathologic Basis of Disease. Sixth Edition. WB Saunders 1999.

Commonly Used Terms

Dermal mucinosis-See term.

Last Updated 4/1/2001

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