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The dermis is a dynamic environment with complex interactions of collagen, blood vessels, elastic fibers, and mucopolysacchardies and ground substance. The family of enzymes known as Matrix Metalloproteinases (MPP) play a major role in maintaining the tight control of events.

From the diagnostic standpoint, the pathologist determines the location of inflammatory cells within the dermis and examines any alterations within the collagen. Putting together a combination of these changes leads to a differential diagnosis. Finally, combining these changes with the clinical history and appearance of the lesion leads to a diagnosis.



Bogle MA, Hwang LY, Tschen JA.

St. Joseph Hospital, and the Department of Dermatology, Baylor College of Medicine.

J Am Acad Dermatol 2002 Sep;47(3):448-51 Abstract quote

Acrokeratoelastoidosis is a genodermatosis characterized by firm papules or plaques on the sides of the hands and feet. Although poorly understood, the lesions may result from an abnormality in the secretion or excretion of elastic material by fibroblasts in the dermis.

In this report, we will present a patient with this rare condition and review the clinical and histopathologic features, cause, and differential diagnosis.

Weedon D. Weedon's Skin Pathology. Churchill Livingstone. 1997.
Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.

Commonly Used Terms


Matrix Metalloproteinases (MPP)


Last Updated 9/18/2002

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