Taken from CAP Today 1999: 13(11)
On Sept. 25, 1998, the FDA approved the use of a genetically engineered monoclonal antibody for the treatment of patients with metastatic breast cancer. These patient's tumors overexpressed the HER2/neu protein. This overexpression qualified these women for treatment with trastuzumab, also known as Herceptin. For the first time, women with this devastating disease have an important treatment option. The determination of HER2/neu status starts with the pathologist. Clinical trials are currently underway to determine whether single agent use of the antibody or a combination of the antibody with other traditional chemotherapeutic agents is efficacious. Preliminary studies have indicated that HER2/neu status may provide guidance in chemotherapy choice. HER2/neu positive women may benefit more with doxorubicin containing regimens, unless there is a contraindication. In addition, there may be improved response to several anticancer drugs such as Taxol, Adriamycin, and Cytotoxin.
Henry JB. Clinical Diagnosis and Management by Laboratory Methods. Twentieth Edition. WB Saunders. 2001.
Rosai J. Ackerman's Surgical Pathology. Ninth Edition. Mosby 2004.
Sternberg S. Diagnostic Surgical Pathology. Fourth Edition. Lipincott Williams and Wilkins 2004.
Robbins Pathologic Basis of Disease. Seventh Edition. WB Saunders 2005.
DeMay RM. The Art and Science of Cytopathology. Volume 1 and 2. ASCP Press. 1996.
Weedon D. Weedon's Skin Pathology Second Edition. Churchill Livingstone. 2002
Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.
Weiss SW and Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. Fourth Edition. Mosby 2001.
Basic Principles of Disease
Learn the basic disease classifications of cancers, infections, and inflammation
Commonly Used Terms
This is a glossary of terms often found in a pathology report.
Learn how a pathologist makes a diagnosis using a microscope
Surgical Pathology Report
Examine an actual biopsy report to understand what each section means
Understand the tools the pathologist utilizes to aid in the diagnosis
How Accurate is My Report?
Pathologists actively oversee every area of the laboratory to ensure your report is accurate
Recent teaching cases and lectures presented in conferences
Last Updated 1/5/2004
Send mail to The Doctor's Doctor with questions or comments about this web site.
Read the Medical Disclaimer.
Copyright © The Doctor's Doctor