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We have come a long way from those test tubes and bunsen burners you played with in school.  These tests include the routine glucose levels to cutting edge cancer screening tests for prostate cancer. In addition, the pathologist has now moved into the realm of molecular biological testing, screening patients for mutations of susceptibility genes for different cancers like breast cancer.


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Gadolinium Magnetic Resonance Contrast Agents Produce Analytic Interference in Multiple Serum Assays

William L. Roberts, MD, PhD
Am J Clin Pathol 2004;121:282-292 Abstract quote

Gadolinium magnetic resonance contrast agents are known to interfere with some clinical chemistry tests, particularly colorimetric assays for serum calcium.

We studied the effects of 4 agents, gadodiamide, gadoversetamide, gadopentetate dimeglumine, and gadoteridol, for interference with multiple serum assays. Gadodiamide and gadoversetamide produced clinically significant negative interference with colorimetric assays for serum angiotensin-converting enzyme, calcium, and zinc. These agents produced clinically significant positive interference in magnesium and total iron binding capacity assays and both positive and negative interference in iron assays. Gadopentetate dimeglumine produced a negative interference with iron assays, and gadopentetate dimeglumine and gadoteridol produced negative interference with a colorimetric zinc assay.

Caution should be exercised when using colorimetric assays for angiotensin-converting enzyme, calcium, iron, magnesium, total iron binding capacity, and zinc in serum samples from patients who have recently received magnetic resonance contrast agents. In general, gadodiamide and gadoversetamide are more likely to produce a clinically significant interference than gadopentetate dimeglumine and gadoteridol. Likewise, certain analytic methods are more prone to interference, while others not affected.

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Basic Principles of Disease
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Commonly Used Terms
This is a glossary of terms often found in a pathology report.

Diagnostic Process
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Surgical Pathology Report
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How Accurate is My Report?
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Got Path?
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Last Updated August 11, 2005

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