The most important disease process affecting the larynx is laryngeal carcinoma. Yet many other disease processes that affect the surrounding structures may also affect the larynx. The larynx is surrounded by the thyroid and several bony and cartilaginous structures. In addition, there are submucosal salivary glands which may give rise to salivary gland tumors.
The larynx lies between the pharynx and trachea. It is divided into three regions.
Site Components Glottic True vocal cords Supraglottic Epiglottis
Ventricular bands (False vocal cords)
Subglottic Area of merging with the trachea (Most poorly defined anatomically)
As the region changes within the larynx, the epithelium covering it also changes.
Site Epithelium Epiglottis Stratified squamous epithelium True vocal cords Stratified squamous epithelium
Few submucosal glands
False cords Ciliated columnar epithelium
Prominent submucosal glands
Neuroendocrine Carcinoma of the Larynx
Commonly Used Terms Internet Links
HISTOPATHOLOGICAL VARIANTS CHARACTERISTICS Chondroid tumors of the larynx: A clinicopathologic study of 19 cases, including two dedifferentiated chondrosarcomas.
Casiraghi O, Martinez-Madrigal F, Pineda-Daboin K, Mamelle G, Resta L, Luna MA.
Ann Diagn Pathol. 2004 Aug;8(4):189-97. Abstract quote
We studied 19 cases of chondroid tumors of the larynx: two chondrometaplastic nodules, two chondromas and 15 chondrosarcomas (including two dedifferentiated chondrosarcomas). One of chondromas recurred 18 months after resection because of inadequate surgical treatment.
Chondrosarcomas were separated as low-grade (nine cases), intermediate (three cases), high-grade (one case), and dedifferentiated (two cases) according to histologic appearance. Chondrosarcomas are nearly always histologically low grade, make up the largest numbers of the neoplasms, and arise from the cricoid cartilage. Conservative surgical management, when possible, is advocated to preserve the larynx.
Chondrometaplastic nodules are to be distinguished from chondrosarcoma and the rarely occurring chondroma. The nodules are not neoplastic and have a low to nil recurrent potential.
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Last Updated September 7, 2004
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