Eosinophilic angiocentric fibrosis (EAF) is a rare submucosal fibrosis. The patients experienced a nasal cavity mass, maxillary pain, or nasal obstructive symptoms of long duration. The process has been reported in the nasal septum, nasal cavity, and/or the maxillary sinus. It does not seem to have systemic associations with known diseases.
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EPIDEMIOLOGY CHARACTERIZATION SYNONYMS EAF AGE RANGE-MEDIAN 28-64 years
HISTOLOGICAL TYPES CHARACTERIZATION General
Characteristic perivascular "onion-skin" fibrosis and a full spectrum of inflammatory cells, although eosinophils predominated
Necrosis and foreign body–type giant cells were not identified
DIFFERENTIAL DIAGNOSIS KEY DIFFERENTIATING FEATURES Wegener granulomatosis Churg-Strauss syndrome Kimura disease Granuloma faciale Erythema elevatum diutinum.
PROGNOSIS AND TREATMENT CHARACTERIZATION Prognostic Factors Survival All alive but with disease at last follow-up Treatment Surgical excision for all patients
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