Background

Eosinophilic angiocentric fibrosis (EAF) is a rare submucosal fibrosis. The patients experienced a nasal cavity mass, maxillary pain, or nasal obstructive symptoms of long duration. The process has been reported in the nasal septum, nasal cavity, and/or the maxillary sinus. It does not seem to have systemic associations with known diseases.

OUTLINE

Epidemiology
Disease Associations
Pathogenesis
Laboratory/Radiologic/ Other Diagnostic Testing
Gross Appearance and Clinical Variants
Histopathological Features and Variants
Special Stains/ Immunohistochemistry/ Electron Microscopy
Differential Diagnosis
Prognosis
Treatment
Commonly Used Terms
Internet Links

EPIDEMIOLOGY	CHARACTERIZATION
SYNONYMS	EAF
AGE RANGE-MEDIAN	28-64 years

 

HISTOLOGICAL TYPES	CHARACTERIZATION
General	Characteristic perivascular "onion-skin" fibrosis and a full spectrum of inflammatory cells, although eosinophils predominated Necrosis and foreign body–type giant cells were not identified
VARIANTS

 

DIFFERENTIAL DIAGNOSIS	KEY DIFFERENTIATING FEATURES
Wegener granulomatosis
Churg-Strauss syndrome
Kimura disease
Granuloma faciale
Erythema elevatum diutinum.

 

PROGNOSIS AND TREATMENT	CHARACTERIZATION
Prognostic Factors
Survival	All alive but with disease at last follow-up
Treatment	Surgical excision for all patients

Am J Clin Pathol 2001;115:243-248
Henry JB. Clinical Diagnosis and Management by Laboratory Methods. Twentieth Edition. WB Saunders. 2001.
Rosai J. Ackerman's Surgical Pathology. Ninth Edition. Mosby 2004.
Sternberg S. Diagnostic Surgical Pathology. Fourth Edition. Lipincott Williams and Wilkins 2004.
Robbins Pathologic Basis of Disease. Seventh Edition. WB Saunders 2005.
DeMay RM. The Art and Science of Cytopathology. Volume 1 and 2. ASCP Press. 1996.
Weedon D. Weedon's Skin Pathology Second Edition. Churchill Livingstone. 2002
Fitzpatrick's Dermatology in General Medicine. 6th Edition. McGraw-Hill. 2003.
Weiss SW and Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. Fourth Edition. Mosby 2001.

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Last Updated 1/5/2004

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