Background

A vesicle begins as spongiosis or intercellular edema. Thus any condition that is classified as a spongiotic dermatitis may eventually become an intraepidermal vesicle or eventually a bullae. Under the microscope, blistering diseases are classified by the location of the blister. Modifying characteristics include an autoimmune etiology, acantholysis, and the type of inflammatory cell.

CATEGORY	DISEASE
AUTOIMMUNE SUBEPIDERMAL BLISTERING DISEASES
	Bullous pemphigoid
	Pemphigoid gestationis (Herpes gestationis)
	Lichen planus pemphigoides
	Linear IgA disease
	Dermatitis herpetiformis
	Cicatricial pemphigoid
	Anti-p200 pemphigoid
	Anti-p105 pemphigoid (Deep Lamina lucida pemphigoid)
	Anti-p450 pemphigoid
	Epidermolysis bullosa acquisita
	Bullous systemic lupus erythematosus
INHERITED SUBEPIDERMAL BLISTERING DISEASES
	Epidermolysis bullosa
	Epidermolysis bullosa simplex Keratin 5 and 14
	Epidermolysis bullosa with muscular dystrophy Plectin
	Epidermolysis bullosa with pyloric atresia alpha6beta4 integrin
	Generalized atrophic benign epidermolysis bullosa BP180 Laminin 5
	Herlitz junctional epidermolysis bullosa Laminin 5
	Dystrophic epidermolysis bullosa Type VII collagen
ACQUIRED SUBEPIDERMAL BLISTERING DISEASES
	Porphyria cutanea tarda
	Bullous diabeticorum
	Drug reaction
AUTOIMMUNE INTRAEPIDERMAL BLISTERING DISEASES WITH ACANTHOLYSIS
	Pemphigus vulgaris
	Pemphigus vegetans
	Pemphigus erythematosus
	Pemphigus foliaceus
	Paraneoplastic pemphigus
INHERITED INTRAEPIDERMAL BLISTERING DISEASES
	Hailey-Hailey disease (Familial benign pemphigus)
	Darier's disease
ACQUIRED INTRAEPIDERMAL BLISTERING DISEASES
	Drug reactions
	Grover's disease
	Warty dyskeratoma

Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.

Skin

Last Updated 2/18/2001

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