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Background

Gianotti-Crosti syndrome (GCS) usually presents with a symmetric erythematous lichenoid papular and papulovesicular eruption of the face, extremities, and buttocks, usually occurring in young children. Since the earliest descriptions, there has been an association with various viral infections, including hepatitis B, enteroviruses, Epstein-Barr virus (EBV) and, rarely, cytomegalovirus and bacterial infections.

OUTLINE

Epidemiology  
Disease Associations  
Histopathological Features and Variants  
Prognosis  
Treatment  
Commonly Used Terms  
Internet Links  

EPIDEMIOLOGY CHARACTERIZATION
SYNONYMS Infantile papular acrodermatitis
AGE RANGE-MEDIAN Younger children

 

DISEASE ASSOCIATIONS CHARACTERIZATION
Epstein-Barr virus J Am Acad Dermatol 2000;43:1076-9.
Hepatitis B virus Arch Dis Child 1973;48:794-9.
Adenovirus  
Respiratory syncytial virus  
Parainfluenza virus  
Parvovirus B19  
Rotavirus  
Rubella virus  
HIV-1  
Bacterial infections Group A -hemolytic streptococci
Mycobacterium avium intracellulare
Immunizations Polio vaccine enterovirus, diphtheria immunization, pertussis immunization, influenza virus immunization

 

HISTOLOGICAL TYPES CHARACTERIZATION
General  
VARIANTS  
Associated with Epstein-Barr virus infection

J Am Acad Dermatol 2000;43:1076-9.
Minimal epidermal spongiosis with marked papillary dermal edema

Associated inflammatory infiltrate showed a mixed mononuclear cell infiltrate with rare eosinophils

Immunohistochemical stains for latent membrane antigen-1 and EBV-encoded nuclear antigen-2 were negative for EBV

The majority of mononuclear cells showed membrane staining for CD3
30% to 40% of the CD3 mononuclear cells showed positive staining for CD4, and 50% to 60% showed positive staining with CD8
TIA+ cells appeared to correspond to the CD8+ cells.

 

PROGNOSIS AND TREATMENT CHARACTERIZATION
Prognostic Factors Self-healing
TREATMENT Supportive

Weedon D. Weedon's Skin Pathology. Churchill Livingstone. 1997.
Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.


Commonly Used Terms

Basic Principles of Disease
Learn the basic disease classifications of cancers, infections, and inflammation

Commonly Used Terms
This is a glossary of terms often found in a pathology report.

Diagnostic Process
Learn how a pathologist makes a diagnosis using a microscope

Surgical Pathology Report
Examine an actual biopsy report to understand what each section means

Special Stains
Understand the tools the pathologist utilizes to aid in the diagnosis

How Accurate is My Report?
Pathologists actively oversee every area of the laboratory to ensure your report is accurate


Internet Links

Last Updated 2/12/2003

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