Gianotti-Crosti syndrome (GCS) usually presents with a symmetric erythematous lichenoid papular and papulovesicular eruption of the face, extremities, and buttocks, usually occurring in young children. Since the earliest descriptions, there has been an association with various viral infections, including hepatitis B, enteroviruses, Epstein-Barr virus (EBV) and, rarely, cytomegalovirus and bacterial infections.
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EPIDEMIOLOGY CHARACTERIZATION SYNONYMS Infantile papular acrodermatitis AGE RANGE-MEDIAN Younger children
DISEASE ASSOCIATIONS CHARACTERIZATION Epstein-Barr virus J Am Acad Dermatol 2000;43:1076-9. Hepatitis B virus Arch Dis Child 1973;48:794-9. Adenovirus Respiratory syncytial virus Parainfluenza virus Parvovirus B19 Rotavirus Rubella virus HIV-1 Bacterial infections Group A -hemolytic streptococci
Mycobacterium avium intracellulare
Immunizations Polio vaccine enterovirus, diphtheria immunization, pertussis immunization, influenza virus immunization
HISTOLOGICAL TYPES CHARACTERIZATION General VARIANTS Associated with Epstein-Barr virus infection
J Am Acad Dermatol 2000;43:1076-9.
Minimal epidermal spongiosis with marked papillary dermal edema
Associated inflammatory infiltrate showed a mixed mononuclear cell infiltrate with rare eosinophils
Immunohistochemical stains for latent membrane antigen-1 and EBV-encoded nuclear antigen-2 were negative for EBV
The majority of mononuclear cells showed membrane staining for CD3
30% to 40% of the CD3 mononuclear cells showed positive staining for CD4, and 50% to 60% showed positive staining with CD8
TIA+ cells appeared to correspond to the CD8+ cells.
PROGNOSIS AND TREATMENT CHARACTERIZATION Prognostic Factors Self-healing TREATMENT Supportive
Weedon D. Weedon's Skin Pathology. Churchill Livingstone. 1997.
Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.
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Last Updated 2/12/2003
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