Although this disease is classically listed under bone tumors, it is not a true neoplasm. It is a developmental abnormality and is one of the more common tumors occurring in the bone.
Dahlin's Bone Tumors 5th Ed. 1996
Study from Mayo Clinic
25% of all benign bone tumors
7% of all biopsied bone tumors
AGE RANGE-MEDIAN 2-3rd decades SEX (M:F) Equal
LABORATORY/RADIOLOGIC/OTHER TESTS CHARACTERIZATION Radiographs
Tumor of flat bones favoring the skull, jawbones, and ribs
Long bones very uncommon
Well circumscribed with/without a sclerotic rim
Hazy ground glass appearance on plain films
Not associated with cortical destruction unless associated with a pathologic fracture
HISTOLOGICAL TYPES CHARACTERIZATION General
Irregularly shaped spicules of woven bone arranged in characteristic "Chinese letters" set in a bland spindle cell stroma
Rarely cartilaginous differentiation
Mitotic figures are extremely rare
DIFFERENTIAL DIAGNOSIS KEY DIFFERENTIATING FEATURES Low grade central osteosarcoma Permeation of pre-existing bony trabeculae or marrow fat
Destroys cortex and invades soft tissue
PROGNOSIS AND TREATMENT CHARACTERIZATION Metastasis
Malignancy has varied from 0.4-6.7% depending upon the series
Treatment Curettage and bone grafting
Lesions in expendable bones may utilize en bloc resection
Pathol Case Rev 2001;6:22-27.
Last Updated 2/21/2001
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