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Background

Although this disease is classically listed under bone tumors, it is not a true neoplasm. It is a developmental abnormality and is one of the more common tumors occurring in the bone.

INCIDENCE

Dahlin's Bone Tumors 5th Ed. 1996

Study from Mayo Clinic
25% of all benign bone tumors
7% of all biopsied bone tumors

AGE RANGE-MEDIAN 2-3rd decades
SEX (M:F)
Equal

 

LABORATORY/RADIOLOGIC/OTHER TESTS CHARACTERIZATION
Radiographs

Tumor of flat bones favoring the skull, jawbones, and ribs
Long bones very uncommon

Well circumscribed with/without a sclerotic rim
Hazy ground glass appearance on plain films

Not associated with cortical destruction unless associated with a pathologic fracture

 

HISTOLOGICAL TYPES CHARACTERIZATION
General

Irregularly shaped spicules of woven bone arranged in characteristic "Chinese letters" set in a bland spindle cell stroma

Rarely cartilaginous differentiation
Mitotic figures are extremely rare

VARIANTS  

 

DIFFERENTIAL DIAGNOSIS KEY DIFFERENTIATING FEATURES
Low grade central osteosarcoma Permeation of pre-existing bony trabeculae or marrow fat
Destroys cortex and invades soft tissue

 

PROGNOSIS AND TREATMENT CHARACTERIZATION
Metastasis

Cancer 1994;73:1411-1424

Malignancy has varied from 0.4-6.7% depending upon the series

Treatment Curettage and bone grafting
Lesions in expendable bones may utilize en bloc resection

Pathol Case Rev 2001;6:22-27.


Commonly Used Terms

Bone Tumors


Last Updated 2/21/2001

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